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Direct catalytic enantioselective amination of ketones for the formation of tri- and tetrasubstituted stereocenters
Herein, we report a Zn–ProPhenol catalyzed direct asymmetric amination reaction of unactivated aryl and vinyl ketones using di-tert-butyl azodicarboxylate as a cheap and practical electrophilic nitrogen source. Importantly, this methodology works with both α-branched and unbranched ketones for the c...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897889/ https://www.ncbi.nlm.nih.gov/pubmed/29719678 http://dx.doi.org/10.1039/c8sc00147b |