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Histone H3K9 and H4 Acetylations and Transcription Facilitate the Initial CENP-A(HCP−3) Deposition and De Novo Centromere Establishment in Caenorhabditis elegans Artificial Chromosomes

BACKGROUND: The centromere is the specialized chromatin region that directs chromosome segregation. The kinetochore assembles on the centromere, attaching chromosomes to microtubules in mitosis. The centromere position is usually maintained through cell cycles and generations. However, new centromer...

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Detalles Bibliográficos
Autores principales: Zhu, Jing, Cheng, Kevin Chi Lok, Yuen, Karen Wing Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898018/
https://www.ncbi.nlm.nih.gov/pubmed/29653589
http://dx.doi.org/10.1186/s13072-018-0185-1