Bile acids at neutral and acidic pH induce apoptosis and gene cleavages in nasopharyngeal epithelial cells: implications in chromosome rearrangement

BACKGROUND: Chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC) while nasopharyngeal reflux is known to be one of the major aetiological factors of CRS. Bile acid (BA), the component of gastric duodenal contents, has been recognised as a carcinogen. BA-induce...

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Detalles Bibliográficos
Autores principales: Tan, Sang-Nee, Sim, Sai-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898073/
https://www.ncbi.nlm.nih.gov/pubmed/29649994
http://dx.doi.org/10.1186/s12885-018-4327-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898073/
https://www.ncbi.nlm.nih.gov/pubmed/29649994
http://dx.doi.org/10.1186/s12885-018-4327-4

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