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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (p<2.2×10(−7)): of these, 16 map outside known risk loci. We make two important observations. First, only five of these signals are driven...

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Autores principales: Mahajan, Anubha, Wessel, Jennifer, Willems, Sara M, Zhao, Wei, Robertson, Neil R, Chu, Audrey Y, Gan, Wei, Kitajima, Hidetoshi, Taliun, Daniel, Rayner, N William, Guo, Xiuqing, Lu, Yingchang, Li, Man, Jensen, Richard A, Hu, Yao, Huo, Shaofeng, Lohman, Kurt K, Zhang, Weihua, Cook, James P, Prins, Bram Peter, Flannick, Jason, Grarup, Niels, Trubetskoy, Vassily Vladimirovich, Kravic, Jasmina, Kim, Young Jin, Rybin, Denis V, Yaghootkar, Hanieh, Müller-Nurasyid, Martina, Meidtner, Karina, Li-Gao, Ruifang, Varga, Tibor V, Marten, Jonathan, Li, Jin, Smith, Albert Vernon, An, Ping, Ligthart, Symen, Gustafsson, Stefan, Malerba, Giovanni, Demirkan, Ayse, Tajes, Juan Fernandez, Steinthorsdottir, Valgerdur, Wuttke, Matthias, Lecoeur, Cécile, Preuss, Michael, Bielak, Lawrence F, Graff, Marielisa, Highland, Heather M, Justice, Anne E, Liu, Dajiang J, Marouli, Eirini, Peloso, Gina Marie, Warren, Helen R, Afaq, Saima, Afzal, Shoaib, Ahlqvist, Emma, Almgren, Peter, Amin, Najaf, Bang, Lia B, Bertoni, Alain G, Bombieri, Cristina, Bork-Jensen, Jette, Brandslund, Ivan, Brody, Jennifer A, Burtt, Noël P, Canouil, Mickaël, da Chen, Yii-Der I, Cho, Yoon Shin, Christensen, Cramer, Eastwood, Sophie V, Eckardt, Kai-Uwe, Fischer, Krista, Gambaro, Giovanni, Giedraitis, Vilmantas, Grove, Megan L, de Haan, Hugoline G, Hackinger, Sophie, Hai, Yang, Han, Sohee, Tybjærg-Hansen, Anne, Hivert, Marie-France, Isomaa, Bo, Jäger, Susanne, Jørgensen, Marit E, Jørgensen, Torben, Käräjämäki, Annemari, Kim, Bong-Jo, Kim, Sung Soo, Koistinen, Heikki A, Kovacs, Peter, Kriebel, Jennifer, Kronenberg, Florian, Läll, Kristi, Lange, Leslie A, Lee, Jung-Jin, Lehne, Benjamin, Li, Huaixing, Lin, Keng-Hung, Linneberg, Allan, Liu, Ching-Ti, Liu, Jun, Loh, Marie, Mägi, Reedik, Mamakou, Vasiliki, McKean-Cowdin, Roberta, Nadkarni, Girish, Neville, Matt, Nielsen, Sune F, Ntalla, Ioanna, Peyser, Patricia A, Rathmann, Wolfgang, Rice, Kenneth, Rich, Stephen S, Rode, Line, Rolandsson, Olov, Schönherr, Sebastian, Selvin, Elizabeth, Small, Kerrin S, Stančáková, Alena, Surendran, Praveen, Taylor, Kent D, Teslovich, Tanya M, Thorand, Barbara, Thorleifsson, Gudmar, Tin, Adrienne, Tönjes, Anke, Varbo, Anette, Witte, Daniel R, Wood, Andrew R, Yajnik, Pranav, Yao, Jie, Yengo, Loïc, Young, Robin, Amouyel, Philippe, Boeing, Heiner, Boerwinkle, Eric, Bottinger, Erwin P, Chowdhury, Rajiv, Collins, Francis S, Dedoussis, George, Dehghan, Abbas, Deloukas, Panos, Ferrario, Marco M, Ferrières, Jean, Florez, Jose C, Frossard, Philippe, Gudnason, Vilmundur, Harris, Tamara B, Heckbert, Susan R, Howson, Joanna M M, Ingelsson, Martin, Kathiresan, Sekar, Kee, Frank, Kuusisto, Johanna, Langenberg, Claudia, Launer, Lenore J, Lindgren, Cecilia M, Männistö, Satu, Meitinger, Thomas, Melander, Olle, Mohlke, Karen L, Moitry, Marie, Morris, Andrew D, Murray, Alison D, de Mutsert, Renée, Orho-Melander, Marju, Owen, Katharine R, Perola, Markus, Peters, Annette, Province, Michael A, Rasheed, Asif, Ridker, Paul M, Rivadineira, Fernando, Rosendaal, Frits R, Rosengren, Anders H, Salomaa, Veikko, Sheu, Wayne H -H, Sladek, Rob, Smith, Blair H, Strauch, Konstantin, Uitterlinden, André G, Varma, Rohit, Willer, Cristen J, Blüher, Matthias, Butterworth, Adam S, Chambers, John Campbell, Chasman, Daniel I, Danesh, John, van Duijn, Cornelia, Dupuis, Josée, Franco, Oscar H, Franks, Paul W, Froguel, Philippe, Grallert, Harald, Groop, Leif, Han, Bok-Ghee, Hansen, Torben, Hattersley, Andrew T, Hayward, Caroline, Ingelsson, Erik, Kardia, Sharon LR, Karpe, Fredrik, Kooner, Jaspal Singh, Köttgen, Anna, Kuulasmaa, Kari, Laakso, Markku, Lin, Xu, Lind, Lars, Liu, Yongmei, Loos, Ruth J F, Marchini, Jonathan, Metspalu, Andres, Mook-Kanamori, Dennis, Nordestgaard, Børge G, Palmer, Colin N A, Pankow, James S, Pedersen, Oluf, Psaty, Bruce M, Rauramaa, Rainer, Sattar, Naveed, Schulze, Matthias B, Soranzo, Nicole, Spector, Timothy D, Stefansson, Kari, Stumvoll, Michael, Thorsteinsdottir, Unnur, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Wareham, Nicholas J, Wilson, James G, Zeggini, Eleftheria, Scott, Robert A, Barroso, Inês, Frayling, Timothy M, Goodarzi, Mark O, Meigs, James B, Boehnke, Michael, Saleheen, Danish, Morris, Andrew P, Rotter, Jerome I, McCarthy, Mark I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898373/
https://www.ncbi.nlm.nih.gov/pubmed/29632382
http://dx.doi.org/10.1038/s41588-018-0084-1