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Estimation of treatment effects in weighted log-rank tests

Non-proportional hazards have been observed in clinical trials. The log-rank test loses power and the standard Cox model generally produces biased estimates under such conditions. Weighted log-rank tests have been utilized to increase the test power; however, it is not intuitive how to interpret the...

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Detalles Bibliográficos
Autores principales: Lin, Ray S., León, Larry F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898500/
https://www.ncbi.nlm.nih.gov/pubmed/29696204
http://dx.doi.org/10.1016/j.conctc.2017.09.004