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Defining information fractions in group sequential clinical trials with multiple endpoints

The group sequential design has been well understood and widely applied in designs of late phase clinical trial to enable potentially early stopping for efficacy or futility. The information fraction (IF) is one of the key elements to determine the decision boundary at the interim analyses. The fami...

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Detalles Bibliográficos
Autores principales: Xu, Tu, Qin, Qin, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898546/
https://www.ncbi.nlm.nih.gov/pubmed/29696161
http://dx.doi.org/10.1016/j.conctc.2018.03.005