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Bayesian adaptive clinical trials of combination treatments

Randomized clinical trials (RCT) increasingly investigate combination therapies. Strong biological rationale or early clinical evidence commonly suggest that the effect of the combination treatment is importantly greater than the maximum effect of any of the individual treatments. While these relati...

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Detalles Bibliográficos
Autores principales: Thorlund, Kristian, Golchi, Shirin, Mills, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898557/
https://www.ncbi.nlm.nih.gov/pubmed/29696213
http://dx.doi.org/10.1016/j.conctc.2017.11.001