Butein activates p53 in hepatocellular carcinoma cells via blocking MDM2-mediated ubiquitination

INTRODUCTION: In this study, we aimed to investigate the effect of butein on p53 in hepatocellular carcinoma (HCC) cells and the related molecular mechanisms by which p53 was activated. METHODS: MTS assay and clonogenic survival assay were used to examine the antitumor activity of butein in vitro. R...

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Detalles Bibliográficos
Autores principales: Zhou, Yuanfeng, Wang, Kuifeng, Zhou, Ni, Huang, Tingting, Zhu, Jiansheng, Li, Jicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898589/
https://www.ncbi.nlm.nih.gov/pubmed/29670376
http://dx.doi.org/10.2147/OTT.S160119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898589/
https://www.ncbi.nlm.nih.gov/pubmed/29670376
http://dx.doi.org/10.2147/OTT.S160119

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