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Butein activates p53 in hepatocellular carcinoma cells via blocking MDM2-mediated ubiquitination
INTRODUCTION: In this study, we aimed to investigate the effect of butein on p53 in hepatocellular carcinoma (HCC) cells and the related molecular mechanisms by which p53 was activated. METHODS: MTS assay and clonogenic survival assay were used to examine the antitumor activity of butein in vitro. R...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898589/ https://www.ncbi.nlm.nih.gov/pubmed/29670376 http://dx.doi.org/10.2147/OTT.S160119 |