Cathepsin D deficiency delays central nervous system myelination by inhibiting proteolipid protein trafficking from late endosome/lysosome to plasma membrane

This study aimed to investigate the role of cathepsin D (CathD) in central nervous system (CNS) myelination and its possible mechanism. By using CathD knockout mice in conjunction with immunohistochemistry, immunocytochemistry and western blot assays, the myelination of the CNS and the development o...

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Detalles Bibliográficos
Autores principales: Guo, Da-Zhi, Xiao, Lin, Liu, Yi-Jun, Shen, Chen, Lou, Hui-Fang, Lv, Yan, Pan, Shu-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898895/
https://www.ncbi.nlm.nih.gov/pubmed/29546879
http://dx.doi.org/10.1038/emm.2017.291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898895/
https://www.ncbi.nlm.nih.gov/pubmed/29546879
http://dx.doi.org/10.1038/emm.2017.291

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