Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

Activation of the NOD-like receptor protein (NLRP3)-inflammasome has been postulated to mediate inflammatory responses to brain damage during ischemic/reperfusion (I/R) injury. We therefore hypothesized that MCC950, a selective NLRP3-inflammasome inhibitor provides protection in mouse model of trans...

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Detalles Bibliográficos
Autores principales: Ismael, Saifudeen, Zhao, Liang, Nasoohi, Sanaz, Ishrat, Tauheed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899150/
https://www.ncbi.nlm.nih.gov/pubmed/29654318
http://dx.doi.org/10.1038/s41598-018-24350-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899150/
https://www.ncbi.nlm.nih.gov/pubmed/29654318
http://dx.doi.org/10.1038/s41598-018-24350-x

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