Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Chemokine receptors typically have multiple ligands. Consequently, treatment with a blocking antibody against a single chemokine is expected to be insufficient for efficacy. Here we show single-chain antibodies can be engineered for broad crossreactivity toward multiple human and mouse proinflammato...

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Detalles Bibliográficos
Autores principales: Angelini, Alessandro, Miyabe, Yoshishige, Newsted, Daniel, Kwan, Byron H., Miyabe, Chie, Kelly, Ryan L., Jamy, Misha N., Luster, Andrew D., Wittrup, K. Dane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899157/
https://www.ncbi.nlm.nih.gov/pubmed/29654232
http://dx.doi.org/10.1038/s41467-018-03687-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899157/
https://www.ncbi.nlm.nih.gov/pubmed/29654232
http://dx.doi.org/10.1038/s41467-018-03687-x

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