hTERT gene knockdown enhances response to radio- and chemotherapy in head and neck cancer cell lines through a DNA damage pathway modification

The aim of the study was to analyze the effect of hTERT gene knockdown in HNSCC cells by using novel in vitro models of head and neck cancer (HNSCC), as well as improving its personalized therapy. To obtain the most efficient knockdown siRNA, shRNA-bearing lentiviral vectors were used. The efficienc...

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Detalles Bibliográficos
Autores principales: Barczak, Wojciech, Sobecka, Agnieszka, Golusinski, Pawel, Masternak, Michal M., Rubis, Blazej, Suchorska, Wiktoria M., Golusinski, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899166/
https://www.ncbi.nlm.nih.gov/pubmed/29654294
http://dx.doi.org/10.1038/s41598-018-24503-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899166/
https://www.ncbi.nlm.nih.gov/pubmed/29654294
http://dx.doi.org/10.1038/s41598-018-24503-y

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