Intracerebroventricular Administration of a 2′-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain

Antisense oligonucleotides (AONs) are versatile molecules that can be used to modulate gene expression by binding to RNA. The therapeutic potential of AONs appears particularly high in the central nervous system, due to excellent distribution and uptake in brain cells, as well as good tolerability i...

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Detalles Bibliográficos
Autores principales: Toonen, Lodewijk J.A., Casaca-Carreira, João, Pellisé-Tintoré, Maria, Mei, Hailiang, Temel, Yasin, Jahanshahi, Ali, van Roon-Mom, Willeke M.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899290/
https://www.ncbi.nlm.nih.gov/pubmed/29565739
http://dx.doi.org/10.1089/nat.2017.0705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899290/
https://www.ncbi.nlm.nih.gov/pubmed/29565739
http://dx.doi.org/10.1089/nat.2017.0705

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