PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors

Necroptosis, a form of regulated necrotic cell death, is governed by RIP1/RIP3-mediated activation of MLKL. However, the signaling process leading to necroptotic death remains to be elucidated. In this study, we found that PUMA, a proapoptotic BH3-only Bcl-2 family member, is transcriptionally activ...

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Detalles Bibliográficos
Autores principales: Chen, Dongshi, Tong, Jingshan, Yang, Liheng, Wei, Liang, Stolz, Donna B., Yu, Jian, Zhang, Jianke, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899441/
https://www.ncbi.nlm.nih.gov/pubmed/29581256
http://dx.doi.org/10.1073/pnas.1717190115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899441/
https://www.ncbi.nlm.nih.gov/pubmed/29581256
http://dx.doi.org/10.1073/pnas.1717190115

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