Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

The development of safe and efficacious gene vectors has limited greatly the potential for therapeutic treatments based on messenger RNA (mRNA). Lipid nanoparticles (LNPs) formed by an ionizable cationic lipid (here DLin-MC3-DMA), helper lipids (distearoylphosphatidylcholine, DSPC, and cholesterol),...

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Detalles Bibliográficos
Autores principales: Yanez Arteta, Marianna, Kjellman, Tomas, Bartesaghi, Stefano, Wallin, Simonetta, Wu, Xiaoqiu, Kvist, Alexander J., Dabkowska, Aleksandra, Székely, Noémi, Radulescu, Aurel, Bergenholtz, Johan, Lindfors, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899464/
https://www.ncbi.nlm.nih.gov/pubmed/29588418
http://dx.doi.org/10.1073/pnas.1720542115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899464/
https://www.ncbi.nlm.nih.gov/pubmed/29588418
http://dx.doi.org/10.1073/pnas.1720542115

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