Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

Intrinsically disordered regions (IDRs) of proteins often regulate function upon posttranslational modifications (PTMs) through interactions with folded domains. An IDR linking two α-helices (α1–α2) of the anti-apoptotic protein, Bcl-xL, experiences several PTMs, which reduce anti-apoptotic activity...

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Detalles Bibliográficos
Autores principales: Follis, Ariele Viacava, Llambi, Fabien, Kalkavan, Halime, Yao, Yong, Phillips, Aaron H., Park, Cheon-Gil, Marassi, Francesca M., Green, Douglas R., Kriwacki, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899648/
https://www.ncbi.nlm.nih.gov/pubmed/29507390
http://dx.doi.org/10.1038/s41589-018-0011-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899648/
https://www.ncbi.nlm.nih.gov/pubmed/29507390
http://dx.doi.org/10.1038/s41589-018-0011-x

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