HIV-1 protease with leucine zipper fused at N-terminus exhibits enhanced linker amino acid-dependent activity

BACKGROUND: HIV-1 protease (PR) activation is triggered by Gag-Pol dimerization. Premature PR activation results in reduced virion yields due to enhanced Gag cleavage. A p6* transframe peptide located directly upstream of protease is believed to play a modulating role in PR activation. Previous repo...

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Detalles Bibliográficos
Autores principales: Yu, Fu-Hsien, Wang, Chin-Tien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899837/
https://www.ncbi.nlm.nih.gov/pubmed/29655366
http://dx.doi.org/10.1186/s12977-018-0413-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899837/
https://www.ncbi.nlm.nih.gov/pubmed/29655366
http://dx.doi.org/10.1186/s12977-018-0413-6

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