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HIV-1 protease with leucine zipper fused at N-terminus exhibits enhanced linker amino acid-dependent activity
BACKGROUND: HIV-1 protease (PR) activation is triggered by Gag-Pol dimerization. Premature PR activation results in reduced virion yields due to enhanced Gag cleavage. A p6* transframe peptide located directly upstream of protease is believed to play a modulating role in PR activation. Previous repo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899837/ https://www.ncbi.nlm.nih.gov/pubmed/29655366 http://dx.doi.org/10.1186/s12977-018-0413-6 |