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Phosphodiesterase‐5 inhibition potentiates cerebrovascular reactivity in chronic traumatic brain injury

BACKGROUND: Traumatic cerebrovascular injury (TCVI), a common consequence of traumatic brain injury (TBI), presents an attractive therapeutic target. Because phosphodiesterase‐5 (PDE5) inhibitors potentiate the action of nitric oxide (NO) produced by endothelial cells, they are candidate therapies f...

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Detalles Bibliográficos
Autores principales: Kenney, Kimbra, Amyot, Franck, Moore, Carol, Haber, Margalit, Turtzo, L. Christine, Shenouda, Christian, Silverman, Erika, Gong, Yunhua, Qu, Bao‐ Xi, Harburg, Leah, Wassermann, Eric M., Lu, Hanzhang, Diaz‐Arrastia, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899908/
https://www.ncbi.nlm.nih.gov/pubmed/29687019
http://dx.doi.org/10.1002/acn3.541