Improved stratification of ALS clinical trials using predicted survival

INTRODUCTION: In small trials, randomization can fail, leading to differences in patient characteristics across treatment arms, a risk that can be reduced by stratifying using key confounders. In ALS trials, riluzole use (RU) and bulbar onset (BO) have been used for stratification. We hypothesized t...

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Detalles Bibliográficos
Autores principales: Berry, James D., Taylor, Albert A., Beaulieu, Danielle, Meng, Lisa, Bian, Amy, Andrews, Jinsy, Keymer, Mike, Ennist, David L., Ravina, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899911/
https://www.ncbi.nlm.nih.gov/pubmed/29687024
http://dx.doi.org/10.1002/acn3.550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899911/
https://www.ncbi.nlm.nih.gov/pubmed/29687024
http://dx.doi.org/10.1002/acn3.550

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