High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation

How T cell receptors (TCRs) are triggered to start signaling is still not fully understood. It has been proposed that segregation of the large membrane tyrosine phosphatase CD45 from engaged TCRs initiates signaling by favoring phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAM...

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Detalles Bibliográficos
Autores principales: Al-Aghbar, Mohammad Ameen, Chu, Yeh-Shiu, Chen, Bing-Mae, Roffler, Steve R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900011/
https://www.ncbi.nlm.nih.gov/pubmed/29686683
http://dx.doi.org/10.3389/fimmu.2018.00713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900011/
https://www.ncbi.nlm.nih.gov/pubmed/29686683
http://dx.doi.org/10.3389/fimmu.2018.00713

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