Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance

Newly generated bone marrow B cells are positively selected into the peripheral lymphoid tissue only when they express a B cell receptor (BCR) that is nonautoreactive or one that binds self-antigen with only minimal avidity. This positive selection process, moreover, is critically contingent on the...

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Detalles Bibliográficos
Autores principales: Greaves, Sarah A., Peterson, Jacob N., Torres, Raul M., Pelanda, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900439/
https://www.ncbi.nlm.nih.gov/pubmed/29686680
http://dx.doi.org/10.3389/fimmu.2018.00707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900439/
https://www.ncbi.nlm.nih.gov/pubmed/29686680
http://dx.doi.org/10.3389/fimmu.2018.00707

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