Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers

The p53 tumor suppressor protein is the most well studied as a regulator of transcription in the nucleus, where it exists primarily as a tetramer. However, there are other oligomeric states of p53 that are relevant to its regulation and activities. In unstressed cells, p53 is normally held in check...

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Detalles Bibliográficos
Autores principales: Katz, Chen, Low-Calle, Ana Maria, Choe, Joshua H., Laptenko, Oleg, Tong, David, Joseph-Chowdhury, Jazmine-Saskya N., Garofalo, Francesca, Zhu, Yan, Friedler, Assaf, Prives, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900715/
https://www.ncbi.nlm.nih.gov/pubmed/29549180
http://dx.doi.org/10.1101/gad.304071.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900715/
https://www.ncbi.nlm.nih.gov/pubmed/29549180
http://dx.doi.org/10.1101/gad.304071.117

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