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Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers
The p53 tumor suppressor protein is the most well studied as a regulator of transcription in the nucleus, where it exists primarily as a tetramer. However, there are other oligomeric states of p53 that are relevant to its regulation and activities. In unstressed cells, p53 is normally held in check...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900715/ https://www.ncbi.nlm.nih.gov/pubmed/29549180 http://dx.doi.org/10.1101/gad.304071.117 |