Differentiation‐associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic‐metabolizing activity of “luminal” muscle‐invasive bladder cancers

Extra‐hepatic metabolism of xenobiotics by epithelial tissues has evolved as a self‐defence mechanism but has potential to contribute to the local activation of carcinogens. Bladder epithelium (urothelium) is bathed in excreted urinary toxicants and pro‐carcinogens. This study reveals how differenti...

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Detalles Bibliográficos
Autores principales: Baker, Simon C., Arlt, Volker M., Indra, Radek, Joel, Madeleine, Stiborová, Marie, Eardley, Ian, Ahmad, Niaz, Otto, Wolfgang, Burger, Maximilian, Rubenwolf, Peter, Phillips, David H., Southgate, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900743/
https://www.ncbi.nlm.nih.gov/pubmed/29323757
http://dx.doi.org/10.1002/mc.22784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900743/
https://www.ncbi.nlm.nih.gov/pubmed/29323757
http://dx.doi.org/10.1002/mc.22784

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