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Ca(V)3.2 drives sustained burst‐firing, which is critical for absence seizure propagation in reticular thalamic neurons
OBJECTIVE: Genetic alterations have been identified in the CACNA1H gene, encoding the Ca(V)3.2 T‐type calcium channel in patients with absence epilepsy, yet the precise mechanisms relating to seizure propagation and spike‐wave‐discharge (SWD) pacemaking remain unknown. Neurons of the thalamic reticu...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900875/ https://www.ncbi.nlm.nih.gov/pubmed/29468672 http://dx.doi.org/10.1111/epi.14018 |