Ca(V)3.2 drives sustained burst‐firing, which is critical for absence seizure propagation in reticular thalamic neurons

OBJECTIVE: Genetic alterations have been identified in the CACNA1H gene, encoding the Ca(V)3.2 T‐type calcium channel in patients with absence epilepsy, yet the precise mechanisms relating to seizure propagation and spike‐wave‐discharge (SWD) pacemaking remain unknown. Neurons of the thalamic reticu...

Descripción completa

Detalles Bibliográficos
Autores principales: Cain, Stuart M., Tyson, John R., Choi, Hyun‐Beom, Ko, Rebecca, Lin, Paulo J. C., LeDue, Jeffrey M., Powell, Kim L., Bernier, Louis‐Philippe, Rungta, Ravi L., Yang, Yi, Cullis, Pieter R., O'Brien, Terence J., MacVicar, Brian A., Snutch, Terrance P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full‐length Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900875/
https://www.ncbi.nlm.nih.gov/pubmed/29468672
http://dx.doi.org/10.1111/epi.14018

Ejemplares similares

Ejemplares similares