Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules

Monoclonal antibodies (mAbs) currently dominate the biopharmaceutical sector due to their potency and efficacy against a range of disease targets. These proteinaceous therapeutics are, however, susceptible to unfolding, mis‐folding, and aggregation by environmental perturbations. Aggregation thus po...

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Detalles Bibliográficos
Autores principales: Willis, Leon F., Kumar, Amit, Dobson, John, Bond, Nicholas J., Lowe, David, Turner, Richard, Radford, Sheena E., Kapur, Nikil, Brockwell, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900942/
https://www.ncbi.nlm.nih.gov/pubmed/29315487
http://dx.doi.org/10.1002/bit.26543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900942/
https://www.ncbi.nlm.nih.gov/pubmed/29315487
http://dx.doi.org/10.1002/bit.26543

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