Genetic ablation of carbonic anhydrase IX disrupts gastric barrier function via claudin‐18 downregulation and acid backflux

AIM: This study aimed to explore the molecular mechanisms for the parietal cell loss and fundic hyperplasia observed in gastric mucosa of mice lacking the carbonic anhydrase 9 (CAIX). METHODS: We assessed the ability of CAIX‐knockout and WT gastric surface epithelial cells to withstand a luminal aci...

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Detalles Bibliográficos
Autores principales: Li, T., Liu, X., Riederer, B., Nikolovska, K., Singh, A. K., Mäkelä, K. A., Seidler, A., Liu, Y., Gros, G., Bartels, H., Herzig, K. H., Seidler, U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Gastrointestinal Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901031/
https://www.ncbi.nlm.nih.gov/pubmed/28748627
http://dx.doi.org/10.1111/apha.12923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901031/
https://www.ncbi.nlm.nih.gov/pubmed/28748627
http://dx.doi.org/10.1111/apha.12923

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