Reduced SERCA activity underlies dysregulation of Ca(2+) homeostasis under atmospheric O(2) levels

Unregulated increases in cellular Ca(2+) homeostasis are a hallmark of pathophysiological conditions and a key trigger of cell death. Endothelial cells cultured under physiologic O(2) conditions (5% O(2)) exhibit a reduced cytosolic Ca(2+) response to stimulation. The mechanism for reduced plateau [...

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Detalles Bibliográficos
Autores principales: Keeley, Thomas P., Siow, Richard C. M., Jacob, Ron, Mann, Giovanni E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901376/
https://www.ncbi.nlm.nih.gov/pubmed/29273673
http://dx.doi.org/10.1096/fj.201700685RRR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901376/
https://www.ncbi.nlm.nih.gov/pubmed/29273673
http://dx.doi.org/10.1096/fj.201700685RRR

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