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Reduced SERCA activity underlies dysregulation of Ca(2+) homeostasis under atmospheric O(2) levels

Unregulated increases in cellular Ca(2+) homeostasis are a hallmark of pathophysiological conditions and a key trigger of cell death. Endothelial cells cultured under physiologic O(2) conditions (5% O(2)) exhibit a reduced cytosolic Ca(2+) response to stimulation. The mechanism for reduced plateau [...

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Detalles Bibliográficos
Autores principales:	Keeley, Thomas P., Siow, Richard C. M., Jacob, Ron, Mann, Giovanni E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Federation of American Societies for Experimental Biology 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901376/ https://www.ncbi.nlm.nih.gov/pubmed/29273673 http://dx.doi.org/10.1096/fj.201700685RRR

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