Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance

Hexose-6-phosphate dehydrogenase (H6PD) produces reduced NADPH in the endoplasmic reticulum (ER) lumen. NADPH constitutes a cofactor for many reducing enzymes, and its inability to traverse biologic membranes makes in situ synthesis of NADPH in the ER lumen indispensable. The H6PD gene is amplified...

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Detalles Bibliográficos
Autores principales: Tsachaki, Maria, Mladenovic, Natasa, Štambergová, Hana, Birk, Julia, Odermatt, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901385/
https://www.ncbi.nlm.nih.gov/pubmed/29295867
http://dx.doi.org/10.1096/fj.201700870RR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901385/
https://www.ncbi.nlm.nih.gov/pubmed/29295867
http://dx.doi.org/10.1096/fj.201700870RR

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