Cargando…
The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1
Mutations in PINK1, which impair its catalytic kinase activity, are causal for autosomal recessive early‐onset Parkinson's disease (PD). Various studies have indicated that the activation of PINK1 could be a useful strategy in treating neurodegenerative diseases, such as PD. Herein, it is shown...
Autores principales: | Barini, Erica, Miccoli, Ageo, Tinarelli, Federico, Mulholland, Katie, Kadri, Hachemi, Khanim, Farhat, Stojanovski, Laste, Read, Kevin D., Burness, Kerry, Blow, Julian J., Mehellou, Youcef, Muqit, Miratul M. K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901409/ https://www.ncbi.nlm.nih.gov/pubmed/29226533 http://dx.doi.org/10.1002/cbic.201700500 |
Ejemplares similares
-
Kinetin Riboside
and Its ProTides Activate the Parkinson’s
Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent
of Mitochondrial Depolarization
por: Osgerby, Laura, et al.
Publicado: (2017) -
Parkinson’s
Disease: Are PINK1 Activators Inching
Closer to the Clinic?
por: Mehellou, Youcef
Publicado: (2023) -
PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease
por: Kazlauskaite, Agne, et al.
Publicado: (2015) -
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand
por: McWilliams, Thomas G., et al.
Publicado: (2018) -
Repurposing the anthelmintic drug niclosamide to combat Helicobacter pylori
por: Tharmalingam, Nagendran, et al.
Publicado: (2018)