Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene

The human C-C chemokine receptor type-5 (CCR5) is the major transmembrane co-receptor that mediates HIV-1 entry into target CD4+ cells. Gene therapy to knock-out the CCR5 gene has shown encouraging results in providing a functional cure for HIV-1 infection. In gene therapy strategies, the initial re...

Descripción completa

Detalles Bibliográficos
Autores principales: Nerys-Junior, Arildo, Braga-Dias, Luciene P., Pezzuto, Paula, Cotta-de-Almeida, Vinícius, Tanuri, Amilcar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2018
Materias:
Genomics and Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901495/
https://www.ncbi.nlm.nih.gov/pubmed/29583154
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901495/
https://www.ncbi.nlm.nih.gov/pubmed/29583154
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0065

Ejemplares similares