Assessment of genetic integrity, splenic phagocytosis and cell death potential of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid and its effect when combined with commercial chemotherapeutics

The increased incidence of cancer and its high treatment costs have encouraged the search for new compounds to be used in adjuvant therapies for this disease. This study discloses the synthesis of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid (IR-01) an...

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Detalles Bibliográficos
Autores principales: Oliveira, Rodrigo Juliano, da Cruz Leite Santos, Naiara, Pesarini, João Renato, de Oliveira, Beatriz Carneiro, Berno, Claudia Rodrigues, de Araújo, Flávio Henrique Souza, da Silveira, Ingridhy Ostaciana Maia Freitas, Nascimento, Raquel Oliveira, Brochado Antoniolli-Silva, Andréia Conceição Milan, Duenhas Monreal, Antônio Carlos, Beatriz, Adilson, de Lima, Dênis Pires, da Silva Gomes, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2018
Materias:
Mutagenesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901497/
https://www.ncbi.nlm.nih.gov/pubmed/29473933
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901497/
https://www.ncbi.nlm.nih.gov/pubmed/29473933
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0091

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