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Sensitivity to sequencing depth in single-cell cancer genomics

BACKGROUND: Querying cancer genomes at single-cell resolution is expected to provide a powerful framework to understand in detail the dynamics of cancer evolution. However, given the high costs currently associated with single-cell sequencing, together with the inevitable technical noise arising fro...

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Detalles Bibliográficos
Autores principales: Alves, João M., Posada, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901877/
https://www.ncbi.nlm.nih.gov/pubmed/29661213
http://dx.doi.org/10.1186/s13073-018-0537-2