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Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
Transient receptor potential mucolipin 1 (TRPML1) is an endo/lysosomal cation channel ubiquitously expressed in mammalian cells(1,2) and its loss-of-function mutations are the direct cause of Type IV mucolipidosis (MLIV), an autosomal recessive lysosomal storage disease(3-6). Here we present the sin...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901962/ https://www.ncbi.nlm.nih.gov/pubmed/29019981 http://dx.doi.org/10.1038/nature24035 |