The Lysosomal Potassium Channel TMEM175 Adopts a Novel Tetrameric Architecture

TMEM175 is a lysosomal K(+) channel important for maintaining the lysosomal membrane potential and pH stability(1). It contains two homologous copies of a six-transmembrane (6-TM) domain, which has no sequence homology to the canonical tetrameric K(+) channels and lacks the TVGYG selectivity filter...

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Detalles Bibliográficos
Autores principales: Lee, Changkeun, Guo, Jiangtao, Zeng, Weizhong, Kim, Sunghoon, She, Ji, Cang, Chunlei, Ren, Dejian, Jiang, Youxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901963/
https://www.ncbi.nlm.nih.gov/pubmed/28723891
http://dx.doi.org/10.1038/nature23269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901963/
https://www.ncbi.nlm.nih.gov/pubmed/28723891
http://dx.doi.org/10.1038/nature23269

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