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Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 cases, 118,538 controls) from ethnically-diverse populations. We identified five new asthma loci, uncovered two additional novel associations at two known asthma loci...

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Autores principales: Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C, Cookson, William OC, Altmüller, Janine, Ang, Wei, Barr, R Graham, Beaty, Terri H, Becker, Allan B, Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bønnelykke, Klaus, Boomsma, Dorret I, Bouzigon, Emmanuelle, Brightling, Christopher E, Brossard, Myriam, Brusselle, Guy G, Burchard, Esteban, Burkart, Kristin M, Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Alves, Alexessander Couto, Curtin, John A, Custovic, Adnan, Daley, Denise, de Jongste, Johan C, Del-Rio-Navarro, Blanca E, Donohue, Kathleen M, Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G, Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A, Freidin, Maxim B, Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A, Gilliland, Frank, Granell, Raquel, Graves, Penelope E, Gudbjartsson, Daniel F, Haahtela, Tari, Heckbert, Susan R, Heederik, Dick, Heinrich, Joachim, Heliövaara, Markku, Henderson, John, Himes, Blanca E, Hirose, Hiroshi, Hirschhorn, Joel N, Hofman, Albert, Holt, Patrick, Hottenga, Jouke Jan, Hudson, Thomas J, Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent WV, James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kähönen, Mika, Kantor, David B, Karunas, Alexandra S, Khusnutdinova, Elza, Koppelman, Gerard H, Kozyrskyj, Anita L, Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimäki, Terho, Letort, Sébastien, Levin, Albert M, Li, Guo, Liang, Liming, Loehr, Laura R, London, Stephanie J, Loth, Daan W, Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J, Matheson, Melanie C, Mathias, Rasika A, Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L, Melbye, Mads, Melén, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W, Myers, Rachel A, Nieuwenhuis, Maartje AE, Noguchi, Emiko, O'Connor, George T, Ogorodova, Ludmila M, Palmer, Cameron D, Palotie, Aarno, Park, Julie E, Pennell, Craig E, Pershagen, Göran, Polonikov, Alexey, Postma, Dirkje S, Probst-Hensch, Nicole, Puzyrev, Valery P, Raby, Benjamin A, Raitakari, Olli T, Ramasamy, Adaikalavan, Rich, Stephen S, Robertson, Colin F, Romieu, Isabelle, Salam, Muhammad T, Salomaa, Veikko, Schlünssen, Vivi, Scott, Robert, Selivanova, Polina A, Sigsgaard, Torben, Simpson, Angela, Siroux, Valérie, Smith, Lewis J, Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P, Stricker, Bruno H, Takahashi, Atsushi, Thompson, Philip J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla MT, Torgerson, Dara G, Tsunoda, Tatsuhiko, Uitterlinden, André G, van der Valk, Ralf JP, Vaysse, Amaury, Vedantam, Sailaja, Von Berg, Andrea, Von Mutius, Erika, Vonk, Judith M, Waage, Johannes, Wareham, Nick J, Weiss, Scott T, White, Wendy B, Wickman, Magnus, Widén, Elisabeth, Willemsen, Gonneke, Williams, L Keoki, Wouters, Inge M, Yang, James J, Zhao, Jing Hua, Moffatt, Miriam F, Ober, Carole, Nicolae, Dan L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974/
https://www.ncbi.nlm.nih.gov/pubmed/29273806
http://dx.doi.org/10.1038/s41588-017-0014-7