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Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 cases, 118,538 controls) from ethnically-diverse populations. We identified five new asthma loci, uncovered two additional novel associations at two known asthma loci...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974/ https://www.ncbi.nlm.nih.gov/pubmed/29273806 http://dx.doi.org/10.1038/s41588-017-0014-7 |
| _version_ | 1783314685435576320 |
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| author | Demenais, Florence Margaritte-Jeannin, Patricia Barnes, Kathleen C Cookson, William OC Altmüller, Janine Ang, Wei Barr, R Graham Beaty, Terri H Becker, Allan B Beilby, John Bisgaard, Hans Bjornsdottir, Unnur Steina Bleecker, Eugene Bønnelykke, Klaus Boomsma, Dorret I Bouzigon, Emmanuelle Brightling, Christopher E Brossard, Myriam Brusselle, Guy G Burchard, Esteban Burkart, Kristin M Bush, Andrew Chan-Yeung, Moira Chung, Kian Fan Alves, Alexessander Couto Curtin, John A Custovic, Adnan Daley, Denise de Jongste, Johan C Del-Rio-Navarro, Blanca E Donohue, Kathleen M Duijts, Liesbeth Eng, Celeste Eriksson, Johan G Farrall, Martin Fedorova, Yuliya Feenstra, Bjarke Ferreira, Manuel A Freidin, Maxim B Gajdos, Zofia Gauderman, Jim Gehring, Ulrike Geller, Frank Genuneit, Jon Gharib, Sina A Gilliland, Frank Granell, Raquel Graves, Penelope E Gudbjartsson, Daniel F Haahtela, Tari Heckbert, Susan R Heederik, Dick Heinrich, Joachim Heliövaara, Markku Henderson, John Himes, Blanca E Hirose, Hiroshi Hirschhorn, Joel N Hofman, Albert Holt, Patrick Hottenga, Jouke Jan Hudson, Thomas J Hui, Jennie Imboden, Medea Ivanov, Vladimir Jaddoe, Vincent WV James, Alan Janson, Christer Jarvelin, Marjo-Riitta Jarvis, Deborah Jones, Graham Jonsdottir, Ingileif Jousilahti, Pekka Kabesch, Michael Kähönen, Mika Kantor, David B Karunas, Alexandra S Khusnutdinova, Elza Koppelman, Gerard H Kozyrskyj, Anita L Kreiner, Eskil Kubo, Michiaki Kumar, Rajesh Kumar, Ashish Kuokkanen, Mikko Lahousse, Lies Laitinen, Tarja Laprise, Catherine Lathrop, Mark Lau, Susanne Lee, Young-Ae Lehtimäki, Terho Letort, Sébastien Levin, Albert M Li, Guo Liang, Liming Loehr, Laura R London, Stephanie J Loth, Daan W Manichaikul, Ani Marenholz, Ingo Martinez, Fernando J Matheson, Melanie C Mathias, Rasika A Matsumoto, Kenji Mbarek, Hamdi McArdle, Wendy L Melbye, Mads Melén, Erik Meyers, Deborah Michel, Sven Mohamdi, Hamida Musk, Arthur W Myers, Rachel A Nieuwenhuis, Maartje AE Noguchi, Emiko O'Connor, George T Ogorodova, Ludmila M Palmer, Cameron D Palotie, Aarno Park, Julie E Pennell, Craig E Pershagen, Göran Polonikov, Alexey Postma, Dirkje S Probst-Hensch, Nicole Puzyrev, Valery P Raby, Benjamin A Raitakari, Olli T Ramasamy, Adaikalavan Rich, Stephen S Robertson, Colin F Romieu, Isabelle Salam, Muhammad T Salomaa, Veikko Schlünssen, Vivi Scott, Robert Selivanova, Polina A Sigsgaard, Torben Simpson, Angela Siroux, Valérie Smith, Lewis J Solodilova, Maria Standl, Marie Stefansson, Kari Strachan, David P Stricker, Bruno H Takahashi, Atsushi Thompson, Philip J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Tiesler, Carla MT Torgerson, Dara G Tsunoda, Tatsuhiko Uitterlinden, André G van der Valk, Ralf JP Vaysse, Amaury Vedantam, Sailaja Von Berg, Andrea Von Mutius, Erika Vonk, Judith M Waage, Johannes Wareham, Nick J Weiss, Scott T White, Wendy B Wickman, Magnus Widén, Elisabeth Willemsen, Gonneke Williams, L Keoki Wouters, Inge M Yang, James J Zhao, Jing Hua Moffatt, Miriam F Ober, Carole Nicolae, Dan L |
| author_facet | Demenais, Florence Margaritte-Jeannin, Patricia Barnes, Kathleen C Cookson, William OC Altmüller, Janine Ang, Wei Barr, R Graham Beaty, Terri H Becker, Allan B Beilby, John Bisgaard, Hans Bjornsdottir, Unnur Steina Bleecker, Eugene Bønnelykke, Klaus Boomsma, Dorret I Bouzigon, Emmanuelle Brightling, Christopher E Brossard, Myriam Brusselle, Guy G Burchard, Esteban Burkart, Kristin M Bush, Andrew Chan-Yeung, Moira Chung, Kian Fan Alves, Alexessander Couto Curtin, John A Custovic, Adnan Daley, Denise de Jongste, Johan C Del-Rio-Navarro, Blanca E Donohue, Kathleen M Duijts, Liesbeth Eng, Celeste Eriksson, Johan G Farrall, Martin Fedorova, Yuliya Feenstra, Bjarke Ferreira, Manuel A Freidin, Maxim B Gajdos, Zofia Gauderman, Jim Gehring, Ulrike Geller, Frank Genuneit, Jon Gharib, Sina A Gilliland, Frank Granell, Raquel Graves, Penelope E Gudbjartsson, Daniel F Haahtela, Tari Heckbert, Susan R Heederik, Dick Heinrich, Joachim Heliövaara, Markku Henderson, John Himes, Blanca E Hirose, Hiroshi Hirschhorn, Joel N Hofman, Albert Holt, Patrick Hottenga, Jouke Jan Hudson, Thomas J Hui, Jennie Imboden, Medea Ivanov, Vladimir Jaddoe, Vincent WV James, Alan Janson, Christer Jarvelin, Marjo-Riitta Jarvis, Deborah Jones, Graham Jonsdottir, Ingileif Jousilahti, Pekka Kabesch, Michael Kähönen, Mika Kantor, David B Karunas, Alexandra S Khusnutdinova, Elza Koppelman, Gerard H Kozyrskyj, Anita L Kreiner, Eskil Kubo, Michiaki Kumar, Rajesh Kumar, Ashish Kuokkanen, Mikko Lahousse, Lies Laitinen, Tarja Laprise, Catherine Lathrop, Mark Lau, Susanne Lee, Young-Ae Lehtimäki, Terho Letort, Sébastien Levin, Albert M Li, Guo Liang, Liming Loehr, Laura R London, Stephanie J Loth, Daan W Manichaikul, Ani Marenholz, Ingo Martinez, Fernando J Matheson, Melanie C Mathias, Rasika A Matsumoto, Kenji Mbarek, Hamdi McArdle, Wendy L Melbye, Mads Melén, Erik Meyers, Deborah Michel, Sven Mohamdi, Hamida Musk, Arthur W Myers, Rachel A Nieuwenhuis, Maartje AE Noguchi, Emiko O'Connor, George T Ogorodova, Ludmila M Palmer, Cameron D Palotie, Aarno Park, Julie E Pennell, Craig E Pershagen, Göran Polonikov, Alexey Postma, Dirkje S Probst-Hensch, Nicole Puzyrev, Valery P Raby, Benjamin A Raitakari, Olli T Ramasamy, Adaikalavan Rich, Stephen S Robertson, Colin F Romieu, Isabelle Salam, Muhammad T Salomaa, Veikko Schlünssen, Vivi Scott, Robert Selivanova, Polina A Sigsgaard, Torben Simpson, Angela Siroux, Valérie Smith, Lewis J Solodilova, Maria Standl, Marie Stefansson, Kari Strachan, David P Stricker, Bruno H Takahashi, Atsushi Thompson, Philip J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Tiesler, Carla MT Torgerson, Dara G Tsunoda, Tatsuhiko Uitterlinden, André G van der Valk, Ralf JP Vaysse, Amaury Vedantam, Sailaja Von Berg, Andrea Von Mutius, Erika Vonk, Judith M Waage, Johannes Wareham, Nick J Weiss, Scott T White, Wendy B Wickman, Magnus Widén, Elisabeth Willemsen, Gonneke Williams, L Keoki Wouters, Inge M Yang, James J Zhao, Jing Hua Moffatt, Miriam F Ober, Carole Nicolae, Dan L |
| author_sort | Demenais, Florence |
| collection | PubMed |
| description | We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 cases, 118,538 controls) from ethnically-diverse populations. We identified five new asthma loci, uncovered two additional novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma risk loci in enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms. |
| format | Online Article Text |
| id | pubmed-5901974 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59019742018-06-22 Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks Demenais, Florence Margaritte-Jeannin, Patricia Barnes, Kathleen C Cookson, William OC Altmüller, Janine Ang, Wei Barr, R Graham Beaty, Terri H Becker, Allan B Beilby, John Bisgaard, Hans Bjornsdottir, Unnur Steina Bleecker, Eugene Bønnelykke, Klaus Boomsma, Dorret I Bouzigon, Emmanuelle Brightling, Christopher E Brossard, Myriam Brusselle, Guy G Burchard, Esteban Burkart, Kristin M Bush, Andrew Chan-Yeung, Moira Chung, Kian Fan Alves, Alexessander Couto Curtin, John A Custovic, Adnan Daley, Denise de Jongste, Johan C Del-Rio-Navarro, Blanca E Donohue, Kathleen M Duijts, Liesbeth Eng, Celeste Eriksson, Johan G Farrall, Martin Fedorova, Yuliya Feenstra, Bjarke Ferreira, Manuel A Freidin, Maxim B Gajdos, Zofia Gauderman, Jim Gehring, Ulrike Geller, Frank Genuneit, Jon Gharib, Sina A Gilliland, Frank Granell, Raquel Graves, Penelope E Gudbjartsson, Daniel F Haahtela, Tari Heckbert, Susan R Heederik, Dick Heinrich, Joachim Heliövaara, Markku Henderson, John Himes, Blanca E Hirose, Hiroshi Hirschhorn, Joel N Hofman, Albert Holt, Patrick Hottenga, Jouke Jan Hudson, Thomas J Hui, Jennie Imboden, Medea Ivanov, Vladimir Jaddoe, Vincent WV James, Alan Janson, Christer Jarvelin, Marjo-Riitta Jarvis, Deborah Jones, Graham Jonsdottir, Ingileif Jousilahti, Pekka Kabesch, Michael Kähönen, Mika Kantor, David B Karunas, Alexandra S Khusnutdinova, Elza Koppelman, Gerard H Kozyrskyj, Anita L Kreiner, Eskil Kubo, Michiaki Kumar, Rajesh Kumar, Ashish Kuokkanen, Mikko Lahousse, Lies Laitinen, Tarja Laprise, Catherine Lathrop, Mark Lau, Susanne Lee, Young-Ae Lehtimäki, Terho Letort, Sébastien Levin, Albert M Li, Guo Liang, Liming Loehr, Laura R London, Stephanie J Loth, Daan W Manichaikul, Ani Marenholz, Ingo Martinez, Fernando J Matheson, Melanie C Mathias, Rasika A Matsumoto, Kenji Mbarek, Hamdi McArdle, Wendy L Melbye, Mads Melén, Erik Meyers, Deborah Michel, Sven Mohamdi, Hamida Musk, Arthur W Myers, Rachel A Nieuwenhuis, Maartje AE Noguchi, Emiko O'Connor, George T Ogorodova, Ludmila M Palmer, Cameron D Palotie, Aarno Park, Julie E Pennell, Craig E Pershagen, Göran Polonikov, Alexey Postma, Dirkje S Probst-Hensch, Nicole Puzyrev, Valery P Raby, Benjamin A Raitakari, Olli T Ramasamy, Adaikalavan Rich, Stephen S Robertson, Colin F Romieu, Isabelle Salam, Muhammad T Salomaa, Veikko Schlünssen, Vivi Scott, Robert Selivanova, Polina A Sigsgaard, Torben Simpson, Angela Siroux, Valérie Smith, Lewis J Solodilova, Maria Standl, Marie Stefansson, Kari Strachan, David P Stricker, Bruno H Takahashi, Atsushi Thompson, Philip J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Tiesler, Carla MT Torgerson, Dara G Tsunoda, Tatsuhiko Uitterlinden, André G van der Valk, Ralf JP Vaysse, Amaury Vedantam, Sailaja Von Berg, Andrea Von Mutius, Erika Vonk, Judith M Waage, Johannes Wareham, Nick J Weiss, Scott T White, Wendy B Wickman, Magnus Widén, Elisabeth Willemsen, Gonneke Williams, L Keoki Wouters, Inge M Yang, James J Zhao, Jing Hua Moffatt, Miriam F Ober, Carole Nicolae, Dan L Nat Genet Article We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 cases, 118,538 controls) from ethnically-diverse populations. We identified five new asthma loci, uncovered two additional novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma risk loci in enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms. 2017-12-22 2018-01 /pmc/articles/PMC5901974/ /pubmed/29273806 http://dx.doi.org/10.1038/s41588-017-0014-7 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Demenais, Florence Margaritte-Jeannin, Patricia Barnes, Kathleen C Cookson, William OC Altmüller, Janine Ang, Wei Barr, R Graham Beaty, Terri H Becker, Allan B Beilby, John Bisgaard, Hans Bjornsdottir, Unnur Steina Bleecker, Eugene Bønnelykke, Klaus Boomsma, Dorret I Bouzigon, Emmanuelle Brightling, Christopher E Brossard, Myriam Brusselle, Guy G Burchard, Esteban Burkart, Kristin M Bush, Andrew Chan-Yeung, Moira Chung, Kian Fan Alves, Alexessander Couto Curtin, John A Custovic, Adnan Daley, Denise de Jongste, Johan C Del-Rio-Navarro, Blanca E Donohue, Kathleen M Duijts, Liesbeth Eng, Celeste Eriksson, Johan G Farrall, Martin Fedorova, Yuliya Feenstra, Bjarke Ferreira, Manuel A Freidin, Maxim B Gajdos, Zofia Gauderman, Jim Gehring, Ulrike Geller, Frank Genuneit, Jon Gharib, Sina A Gilliland, Frank Granell, Raquel Graves, Penelope E Gudbjartsson, Daniel F Haahtela, Tari Heckbert, Susan R Heederik, Dick Heinrich, Joachim Heliövaara, Markku Henderson, John Himes, Blanca E Hirose, Hiroshi Hirschhorn, Joel N Hofman, Albert Holt, Patrick Hottenga, Jouke Jan Hudson, Thomas J Hui, Jennie Imboden, Medea Ivanov, Vladimir Jaddoe, Vincent WV James, Alan Janson, Christer Jarvelin, Marjo-Riitta Jarvis, Deborah Jones, Graham Jonsdottir, Ingileif Jousilahti, Pekka Kabesch, Michael Kähönen, Mika Kantor, David B Karunas, Alexandra S Khusnutdinova, Elza Koppelman, Gerard H Kozyrskyj, Anita L Kreiner, Eskil Kubo, Michiaki Kumar, Rajesh Kumar, Ashish Kuokkanen, Mikko Lahousse, Lies Laitinen, Tarja Laprise, Catherine Lathrop, Mark Lau, Susanne Lee, Young-Ae Lehtimäki, Terho Letort, Sébastien Levin, Albert M Li, Guo Liang, Liming Loehr, Laura R London, Stephanie J Loth, Daan W Manichaikul, Ani Marenholz, Ingo Martinez, Fernando J Matheson, Melanie C Mathias, Rasika A Matsumoto, Kenji Mbarek, Hamdi McArdle, Wendy L Melbye, Mads Melén, Erik Meyers, Deborah Michel, Sven Mohamdi, Hamida Musk, Arthur W Myers, Rachel A Nieuwenhuis, Maartje AE Noguchi, Emiko O'Connor, George T Ogorodova, Ludmila M Palmer, Cameron D Palotie, Aarno Park, Julie E Pennell, Craig E Pershagen, Göran Polonikov, Alexey Postma, Dirkje S Probst-Hensch, Nicole Puzyrev, Valery P Raby, Benjamin A Raitakari, Olli T Ramasamy, Adaikalavan Rich, Stephen S Robertson, Colin F Romieu, Isabelle Salam, Muhammad T Salomaa, Veikko Schlünssen, Vivi Scott, Robert Selivanova, Polina A Sigsgaard, Torben Simpson, Angela Siroux, Valérie Smith, Lewis J Solodilova, Maria Standl, Marie Stefansson, Kari Strachan, David P Stricker, Bruno H Takahashi, Atsushi Thompson, Philip J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Tiesler, Carla MT Torgerson, Dara G Tsunoda, Tatsuhiko Uitterlinden, André G van der Valk, Ralf JP Vaysse, Amaury Vedantam, Sailaja Von Berg, Andrea Von Mutius, Erika Vonk, Judith M Waage, Johannes Wareham, Nick J Weiss, Scott T White, Wendy B Wickman, Magnus Widén, Elisabeth Willemsen, Gonneke Williams, L Keoki Wouters, Inge M Yang, James J Zhao, Jing Hua Moffatt, Miriam F Ober, Carole Nicolae, Dan L Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks |
| title | Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks |
| title_full | Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks |
| title_fullStr | Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks |
| title_full_unstemmed | Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks |
| title_short | Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks |
| title_sort | multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974/ https://www.ncbi.nlm.nih.gov/pubmed/29273806 http://dx.doi.org/10.1038/s41588-017-0014-7 |
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multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT lathropmark multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT laususanne multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT leeyoungae multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT lehtimakiterho multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT letortsebastien multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT levinalbertm multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT liguo multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT liangliming multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT loehrlaurar multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT londonstephaniej multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT lothdaanw multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT manichaikulani multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT marenholzingo multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT martinezfernandoj multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT mathesonmelaniec multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT mathiasrasikaa multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT matsumotokenji multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT mbarekhamdi multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT mcardlewendyl multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT melbyemads multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT melenerik multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT meyersdeborah multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT michelsven multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT mohamdihamida multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT muskarthurw multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT myersrachela multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT nieuwenhuismaartjeae multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT noguchiemiko multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT oconnorgeorget multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT ogorodovaludmilam multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT palmercamerond multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT palotieaarno multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT parkjuliee multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT pennellcraige multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT pershagengoran multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT polonikovalexey multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT postmadirkjes multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT probsthenschnicole multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT puzyrevvaleryp multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT rabybenjamina multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT raitakariollit multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT ramasamyadaikalavan multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT richstephens multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT robertsoncolinf multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT romieuisabelle multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT salammuhammadt multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT salomaaveikko multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT schlunssenvivi multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT scottrobert multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT selivanovapolinaa multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT sigsgaardtorben multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT simpsonangela multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT sirouxvalerie multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT smithlewisj multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT solodilovamaria multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT standlmarie multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT stefanssonkari multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT strachandavidp multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT strickerbrunoh multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT takahashiatsushi multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT thompsonphilipj multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT thorleifssongudmar multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT thorsteinsdottirunnur multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT tieslercarlamt multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT torgersondarag multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT tsunodatatsuhiko multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT uitterlindenandreg multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT vandervalkralfjp multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT vaysseamaury multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT vedantamsailaja multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT vonbergandrea multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT vonmutiuserika multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT vonkjudithm multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT waagejohannes multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT warehamnickj multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT weissscottt multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT whitewendyb multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT wickmanmagnus multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT widenelisabeth multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT willemsengonneke multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT williamslkeoki multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT woutersingem multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT yangjamesj multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT zhaojinghua multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT moffattmiriamf multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT obercarole multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks AT nicolaedanl multiancestryassociationstudyidentifiesnewasthmarisklocithatcolocalizewithimmunecellenhancermarks |