Degenerate Pax2 and Senseless binding motifs improve detection of low-affinity sites required for enhancer specificity

Cells use thousands of regulatory sequences to recruit transcription factors (TFs) and produce specific transcriptional outcomes. Since TFs bind degenerate DNA sequences, discriminating functional TF binding sites (TFBSs) from background sequences represents a significant challenge. Here, we show th...

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Detalles Bibliográficos
Autores principales: Zandvakili, Arya, Campbell, Ian, Gutzwiller, Lisa M., Weirauch, Matthew T., Gebelein, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902045/
https://www.ncbi.nlm.nih.gov/pubmed/29617378
http://dx.doi.org/10.1371/journal.pgen.1007289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902045/
https://www.ncbi.nlm.nih.gov/pubmed/29617378
http://dx.doi.org/10.1371/journal.pgen.1007289

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