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Degenerate Pax2 and Senseless binding motifs improve detection of low-affinity sites required for enhancer specificity
Cells use thousands of regulatory sequences to recruit transcription factors (TFs) and produce specific transcriptional outcomes. Since TFs bind degenerate DNA sequences, discriminating functional TF binding sites (TFBSs) from background sequences represents a significant challenge. Here, we show th...
Autores principales: | Zandvakili, Arya, Campbell, Ian, Gutzwiller, Lisa M., Weirauch, Matthew T., Gebelein, Brian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902045/ https://www.ncbi.nlm.nih.gov/pubmed/29617378 http://dx.doi.org/10.1371/journal.pgen.1007289 |
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