Differences in Local and Systemic TFV PK Among Premenopausal Versus Postmenopausal Women Exposed to TFV 1% Vaginal Gel

OBJECTIVE: We describe and compare the local and systemic pharmacokinetics (PK) of tenofovir (TFV) and TFV-diphosphate (TFV-DP) in healthy premenopausal (PRE) and postmenopausal (POST) women using TFV 1% gel and correlate local PK with other mucosal end points. METHODS: PRE (n = 20) and POST (n = 17...

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Detalles Bibliográficos
Autores principales: Thurman, Andrea Ries, Chandra, Neelima, Yousefieh, Nazita, Kimble, Thomas, Anderson, Sharon M., Cottrell, Mackenzie, Sykes, Craig, Kashuba, Angela, Schwartz, Jill L., Doncel, Gustavo F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2018
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902131/
https://www.ncbi.nlm.nih.gov/pubmed/29424790
http://dx.doi.org/10.1097/QAI.0000000000001648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902131/
https://www.ncbi.nlm.nih.gov/pubmed/29424790
http://dx.doi.org/10.1097/QAI.0000000000001648

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