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Differences in Local and Systemic TFV PK Among Premenopausal Versus Postmenopausal Women Exposed to TFV 1% Vaginal Gel
OBJECTIVE: We describe and compare the local and systemic pharmacokinetics (PK) of tenofovir (TFV) and TFV-diphosphate (TFV-DP) in healthy premenopausal (PRE) and postmenopausal (POST) women using TFV 1% gel and correlate local PK with other mucosal end points. METHODS: PRE (n = 20) and POST (n = 17...
Autores principales: | Thurman, Andrea Ries, Chandra, Neelima, Yousefieh, Nazita, Kimble, Thomas, Anderson, Sharon M., Cottrell, Mackenzie, Sykes, Craig, Kashuba, Angela, Schwartz, Jill L., Doncel, Gustavo F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JAIDS Journal of Acquired Immune Deficiency Syndromes
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902131/ https://www.ncbi.nlm.nih.gov/pubmed/29424790 http://dx.doi.org/10.1097/QAI.0000000000001648 |
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