Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks or exposes myosin binding sites on actin. Findings suggest that electrostatic contacts, particularly those between K326, K328, and R147 on actin and tropomyosin, establish an energeti...

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Detalles Bibliográficos
Autores principales: Viswanathan, Meera C., Schmidt, William, Rynkiewicz, Michael J., Agarwal, Karuna, Gao, Jian, Katz, Joseph, Lehman, William, Cammarato, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902318/
https://www.ncbi.nlm.nih.gov/pubmed/28903042
http://dx.doi.org/10.1016/j.celrep.2017.08.070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902318/
https://www.ncbi.nlm.nih.gov/pubmed/28903042
http://dx.doi.org/10.1016/j.celrep.2017.08.070

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