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Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy
Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks or exposes myosin binding sites on actin. Findings suggest that electrostatic contacts, particularly those between K326, K328, and R147 on actin and tropomyosin, establish an energeti...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902318/ https://www.ncbi.nlm.nih.gov/pubmed/28903042 http://dx.doi.org/10.1016/j.celrep.2017.08.070 |