Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Although many reports have revealed the importance of defective microglia-mediated amyloid β phagocytosis in Alzheimer’s disease (AD), the underlying mechanism remains to be explored. Here we demonstrate that neurons in the brains of patients with AD and AD mice show reduction of sphingosine kinase1...

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Detalles Bibliográficos
Autores principales: Lee, Ju Youn, Han, Seung Hoon, Park, Min Hee, Baek, Bosung, Song, Im-Sook, Choi, Min-Koo, Takuwa, Yoh, Ryu, Hoon, Kim, Seung Hyun, He, Xingxuan, Schuchman, Edward H., Bae, Jae-Sung, Jin, Hee Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902554/
https://www.ncbi.nlm.nih.gov/pubmed/29662056
http://dx.doi.org/10.1038/s41467-018-03674-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902554/
https://www.ncbi.nlm.nih.gov/pubmed/29662056
http://dx.doi.org/10.1038/s41467-018-03674-2

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