Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm

We and others have shown that transition and maintenance of biological states is controlled by master regulator proteins, which can be inferred by interrogating tissue-specific regulatory models (interactomes) with transcriptional signatures, using the VIPER algorithm. Yet, some tissues may lack mol...

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Detalles Bibliográficos
Autores principales: Ding, Hongxu, Douglass, Eugene F., Sonabend, Adam M., Mela, Angeliki, Bose, Sayantan, Gonzalez, Christian, Canoll, Peter D., Sims, Peter A., Alvarez, Mariano J., Califano, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902599/
https://www.ncbi.nlm.nih.gov/pubmed/29662057
http://dx.doi.org/10.1038/s41467-018-03843-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902599/
https://www.ncbi.nlm.nih.gov/pubmed/29662057
http://dx.doi.org/10.1038/s41467-018-03843-3

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