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Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm
We and others have shown that transition and maintenance of biological states is controlled by master regulator proteins, which can be inferred by interrogating tissue-specific regulatory models (interactomes) with transcriptional signatures, using the VIPER algorithm. Yet, some tissues may lack mol...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902599/ https://www.ncbi.nlm.nih.gov/pubmed/29662057 http://dx.doi.org/10.1038/s41467-018-03843-3 |